Alpha-1 Protein Levels Explained
Here's what you'll learn on this page:
Your SERPINA1 genotype—the genetic variants you inherited—can affect how much alpha-1 antitrypsin your body has. Your letters (genetic variant) and numbers (alpha-1 protein levels) together can help your doctor understand your potential Alpha-1 risk
Knowing your alpha-1 protein levels helps you understand your level of lung protection from inflammation and environmental exposure
Most non-Alphas (those with MM genotype) have AAT levels above 20 μM
Below-normal alpha-1 protein levels may mean more risk of lung damage over time. Talk with your doctor about what your alpha-1 protein level and genotype may mean for your lung health
Are your Alpha-1 antitrypsin deficiency (Alpha-1) protein levels leaving you exposed?
The lower your alpha-1 protein levels, the higher your risk.
Your genotype and alpha-1 protein levels together determine your potential risk of lung damage. Alpha-1 protein plays a key role in helping to protect your lung tissue from inflammation and environmental exposures. Your genotype controls how much alpha-1 protein your body has. When your levels are below normal, that protection weakens, which means your lungs may be more at risk over time.
NORMAL levels: 20-53 micromoles per liter (μM)
BELOW-NORMAL levels: below 20 μM
Living with below-normal alpha-1 protein levels means lung changes can happen gradually. These changes may not feel noticeable day-to-day. This is why awareness and monitoring are so important.
The good news? Knowing your levels and staying informed gives you more control. Tracking changes in your breathing, energy, and overall health can help you catch problems early and work with your doctor on the best plan for you.
Ready to learn more about what this means for your lungs?
Why do some people have below-normal alpha-1 protein levels?
The letters (genetic variant) you inherited from your parents—shown below—determine how much alpha-1 protein your body has. Some combinations mean lower numbers (alpha-1 protein levels) and a higher chance of lung changes over time. Here's how they compare:
